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The female cat, therefore, can have the orange mutant gene on one X chromosome and the gene for a black coat on the other.

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Short Hair

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Because genetic determination of coat colors in calico cats is linked to the X chromosome , calicos are nearly always female, with one color linked to the maternal X chromosome and a second color linked to the paternal X chromosome.

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Description: It is currently impossible to reproduce the fur patterns of calico cats by cloning. Penelope Tsernoglou wrote "This is due to an effect called x-linked inactivation which involves the random inactivation of one of the X chromosomes.

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